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Image Search Results
Journal: Cancers
Article Title: Inhibition of Tumor Microenvironment Cytokine Signaling Sensitizes Ovarian Cancer Cells to Antiestrogen Therapy
doi: 10.3390/cancers14194675
Figure Lengend Snippet: Letrozole and ruxolitinib demonstrate synergy in ovarian cancer cell lines. ERα-high ovarian cancer cell lines OVCAR3 and OVCAR8 were treated with a range of doses of ruxolitinib (Rux) and letrozole (Let) at ratio of 1:2 and cell viability quantified by MTT assay. The combination index (CI) was determined using Compusyn applying the Chou-Talalay method. ( A ) The CI relative to the fraction affected (Fa) is shown for OVCAR3 and OVCAR8. CI at 75% inhibition for each cell line is shown, with values < 1 indicating synergy. ( B ) Colony formation assay for OVCAR8 and graphical representation demonstrating synergy in the colony formation assay.
Article Snippet: Cell viability was determined with the
Techniques: MTT Assay, Inhibition, Colony Assay